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Spermatogenesis Associated Protein 18 (SPATA18)

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MIEAP; Mitochondria-eating protein

Spermatogenesis Associated Protein 18 (SPATA18)
CCC M861
HGNC 29579
MGI 1920722
PubMed 16088906
RGD 735208
UniProt Q8TC71
SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63. The transcription factor p53 functions not only to suppress tumorigenesis but also to maintain normal development and homeostasis. Although p53 was implicated in different aspects of fertility, including spermatogenesis and implantation, the mechanism underlying p53 involvement in spermatogenesis is poorly resolved.
SPATA18, as a novel p53 transcriptional target and show that SPATA18 transcription is induced by p53 in a variety of cell types of both human and mouse origin. p53 binds a consensus DNA motif that resides within the first intron of SPATA18.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermatogenesis Associated Protein 18 (SPATA18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermatogenesis Associated Protein 18 (SPATA18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermatogenesis Associated Protein 18 (SPATA18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermatogenesis Associated Protein 18 (SPATA18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermatogenesis Associated Protein 18 (SPATA18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermatogenesis Associated Protein 18 (SPATA18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermatogenesis Associated Protein 18 (SPATA18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermatogenesis Associated Protein 18 (SPATA18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermatogenesis Associated Protein 18 (SPATA18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermatogenesis Associated Protein 18 (SPATA18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermatogenesis Associated Protein 18 (SPATA18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermatogenesis Associated Protein 18 (SPATA18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermatogenesis Associated Protein 18 (SPATA18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermatogenesis Associated Protein 18 (SPATA18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermatogenesis Associated Protein 18 (SPATA18) ELISA Kit Customized Service Offer
  1. "Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control."PLoS ONE 6:E16054-E16054(2011) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63."Mol. Cell. Biol. 31:1679-1689(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria."PLoS ONE 6:E16060-E16060(2011) [PubMed] [Europe PMC] [Abstract]
  7. "BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria."PLoS ONE 7:E30767-E30767(2012) [PubMed] [Europe PMC] [Abstract]