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Ankyrin Repeat Rich Membrane Spanning Protein (ARMS)

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KIDINS220; Kinase D-Interacting Substrate 220kDa

Ankyrin Repeat Rich Membrane Spanning Protein (ARMS)
CCC M849
HGNC 29508
MGI 1924730
PubMed 22699907
RGD 619949
UniProt Q9ULH0
ARMS abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Rich Membrane Spanning Protein (ARMS) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma."Cancer Res. 67:11547-11556(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]