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Trinucleotide Repeat Containing Protein 6C (TNRC6C)

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Trinucleotide Repeat Containing Protein 6C (TNRC6C)
CCC M818
HGNC 29318
MGI 2443265
PubMed 19304925
UniProt Q9HCJ0
By sequencing clones obtained from a fetal brain cDNA library, Nagase et al. (2000) cloned TNRC6C, which they designated KIAA1582. The deduced 1,448-amino acid protein contains an RNA recognition motif and a ubiquitin-associated (UBA) domain. RT-PCR ELISA detected moderate expression in heart, kidney, testis, ovary, adult and fetal brain, and all specific adult brain regions examined. Low expression was detected in skeletal muscle, and no expression was detected in lung, liver, pancreas, spleen, and fetal liver.
Schneider et al. (2006) stated that the TNRC6C protein contains a glycine/tryptophan (GW)-rich N-terminal domain, followed by a UBA domain, a glutamine-rich region, and a C-terminal RNA recognition motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trinucleotide Repeat Containing Protein 6C (TNRC6C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trinucleotide Repeat Containing Protein 6C (TNRC6C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trinucleotide Repeat Containing Protein 6C (TNRC6C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trinucleotide Repeat Containing Protein 6C (TNRC6C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trinucleotide Repeat Containing Protein 6C (TNRC6C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trinucleotide Repeat Containing Protein 6C (TNRC6C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trinucleotide Repeat Containing Protein 6C (TNRC6C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trinucleotide Repeat Containing Protein 6C (TNRC6C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trinucleotide Repeat Containing Protein 6C (TNRC6C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trinucleotide Repeat Containing Protein 6C (TNRC6C) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation."Mol. Cell 35:868-880(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression."RNA 15:781-793(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins."RNA 15:1059-1066(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets."Mol. Cell 44:120-133(2011) [PubMed] [Europe PMC] [Abstract]
  12. "miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT."Nat. Struct. Mol. Biol. 18:1211-1217(2011) [PubMed] [Europe PMC] [Abstract]
  13. "miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs."Nat. Struct. Mol. Biol. 18:1218-1226(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the UBA domain in the human trinucleotide repeat containing 6C protein (HTNRC6C)."Submitted (OCT-2006) to the PDB data bank