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Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1)

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SAPS1; SAP190; PP6R1; SAPS Domain Family Member 1; Serine/threonine-protein phosphatase 6 regulatory subunit 1

Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1)
CCC M799
HGNC 29195
MGI 2442163
RGD 1311409
UniProt Q9UPN7
Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C).
The deduced 829-amino acid protein has a central alpha-helical SAPS domain of about 400 amino acids. Northern blot analysis detected a 4-kb transcript that was highly expressed in testis and moderately expressed in all other tissues examined. Western blot analysis of fractionated HeLa and HEK293 cells showed PP6R1 in the cytosolic fraction.The transcript contains a repetitive element in its 5-prime end, and the deduced protein contains 754 amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 6, Regulatory Subunit 1 (PPP6R1) ELISA Kit Customized Service Offer
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  4. "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon."J. Biol. Chem. 281:22624-22634(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains."Biochemistry 47:1442-1451(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]