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FANCD2/FANCI Associated Nuclease 1 (FAN1)

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MTMR15; Myotubularin Related Protein 15; Fanconi-associated nuclease 1

FANCD2/FANCI Associated Nuclease 1 (FAN1)
CCC M796
HGNC 29170
MGI 3045266
PubMed 22772369
RGD 1566323
UniProt Q9Y2M0
Wiki FAN1
Fanconi anemia (FA) is caused by mutations in 13 Fanc genes and renders cells hypersensitive to DNA interstrand cross-linking (ICL) agents. A central event in the FA pathway is mono-ubiquitylation of the FANCI-FANCD2 (ID) protein complex. Fanconi anemia–associated nuclease 1 (FAN1), that promotes ICL repair in a manner strictly dependent on its ability to accumulate at or near sites of DNA damage and that relies on mono-ubiquitylation of the ID complex. Thus, the mono-ubiquitylated ID complex recruits the downstream repair protein FAN1 and facilitates the repair of DNA interstrand cross-links. FAN1 exhibits a domain architecture suggestive of a role in DNA repair, bearing a RAD18-like ubiquitin-binding (UBZ) domain, a putative DNA-binding (SAP) domain, and a nuclease domain of the VRR_nuc family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FANCD2/FANCI Associated Nuclease 1 (FAN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FANCD2/FANCI Associated Nuclease 1 (FAN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FANCD2/FANCI Associated Nuclease 1 (FAN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FANCD2/FANCI Associated Nuclease 1 (FAN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FANCD2/FANCI Associated Nuclease 1 (FAN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FANCD2/FANCI Associated Nuclease 1 (FAN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FANCD2/FANCI Associated Nuclease 1 (FAN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FANCD2/FANCI Associated Nuclease 1 (FAN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FANCD2/FANCI Associated Nuclease 1 (FAN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FANCD2/FANCI Associated Nuclease 1 (FAN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FANCD2/FANCI Associated Nuclease 1 (FAN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FANCD2/FANCI Associated Nuclease 1 (FAN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FANCD2/FANCI Associated Nuclease 1 (FAN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FANCD2/FANCI Associated Nuclease 1 (FAN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FANCD2/FANCI Associated Nuclease 1 (FAN1) ELISA Kit Customized Service Offer
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  5. "Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2."Cell 142:65-76(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents."Cell 142:77-88(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Human KIAA1018/FAN1 localizes to stalled replication forks via its ubiquitin-binding domain."Cell Cycle 9:3977-3983(2010) [PubMed] [Europe PMC] [Abstract]
  8. "A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair."Mol. Cell 39:36-47(2010) [PubMed] [Europe PMC] [Abstract]
  9. "FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair."Science 329:693-696(2010) [PubMed] [Europe PMC] [Abstract]
  10. "KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents."Proc. Natl. Acad. Sci. U.S.A. 107:21553-21557(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1)."Ai Zheng 31:440-448(2012) [PubMed] [Europe PMC] [Abstract]
  12. "FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain."Cell Rep. 8:84-93(2014) [PubMed] [Europe PMC] [Abstract]
  13. "FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks."Mol. Cell. Biol. 34:3939-3954(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism."Proc. Natl. Acad. Sci. U.S.A. 111:343-348(2014) [PubMed] [Europe PMC] [Abstract]
  15. "DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1."Science 346:1127-1130(2014) [PubMed] [Europe PMC] [Abstract]
  16. "FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair." Nat. Genet. 44:910-915(2012) [PubMed] [Europe PMC] [Abstract]