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EH Domain Binding Protein 1 (EHBP1)

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NACSIN

EH Domain Binding Protein 1 (EHBP1)
CCC M790
HGNC 29144
MGI 2667252
PubMed 23788431
RGD 1310604
UniProt Q8NDI1
The deduced 1,196-amino acid protein has a calculated molecular mass of 136 kD. It contains an N-terminal region with 5 closely spaced EH domain-binding NPF motifs, a central calponin homology (CH) domain, and a C-terminal CAAX box. EHBP1 associated mostly with the cytosol and membrane fractions of transfected COS-1 cells, and it colocalized with EH domain-containing protein-2 (EHD2) in mouse adipocytes.
NPF motifs of EHBP1 bound the EH domain of EHD2. Overexpression of the EH domain of EHD2 or the NPF motifs of EHBP1 disrupted cortical actin structures, and depletion of Ehd2 or Ehbp1 in mouse adipocytes by small interfering RNA inhibited endocytosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EH Domain Binding Protein 1 (EHBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EH Domain Binding Protein 1 (EHBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EH Domain Binding Protein 1 (EHBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EH Domain Binding Protein 1 (EHBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for EH Domain Binding Protein 1 (EHBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EH Domain Binding Protein 1 (EHBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EH Domain Binding Protein 1 (EHBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EH Domain Binding Protein 1 (EHBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EH Domain Binding Protein 1 (EHBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for EH Domain Binding Protein 1 (EHBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EH Domain Binding Protein 1 (EHBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EH Domain Binding Protein 1 (EHBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EH Domain Binding Protein 1 (EHBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EH Domain Binding Protein 1 (EHBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for EH Domain Binding Protein 1 (EHBP1) ELISA Kit Customized Service Offer
  1. "EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton."J. Biol. Chem. 279:10593-10605(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the CH domain from human EH domain binding protein 1."Submitted (JUN-2006) to the PDB data bank
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer." Nat. Genet. 40:281-283(2008) [PubMed] [Europe PMC] [Abstract]