Ankyrin Repeat Domain Protein 12 (ANKRD12)

By sequencing clones obtained from a size-fractionated human brain cDNA library, Nagase et al. (1998) cloned ANKRD12, which they designated KIAA0874. The deduced protein contains 601 amino acids. RT-PCR ELISA detected moderate expression in brain, kidney, heart, lung, liver, testis, and ovary. Low expression was detected in skeletal muscle, pancreas, and spleen.

Using the p19(Arf) isoform of mouse Cdkn2a as bait in a yeast 2-hybrid screen of a mouse embryonic fibroblast cDNA library, Tompkins et al. (2006) cloned Ankrd12. The deduced protein contains an ankyrin repeat. Tompkins et al. (2006) referred to Ankrd12 as Anco1.