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Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5)

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GEF720; Guanine nucleotide exchange factor 720

Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5)
CCC M786
HGNC 29105
MGI 2652860
PubMed 23777631
RGD 1303132
UniProt O94827
By sequencing clones obtained from a size-fractionated brain cDNA library, Nagase et al. (1998) cloned PLEKHG5, which they called KIAA0720. The 3-prime end of the transcript contains repetitive elements, and the protein contains 864 amino acids. RT-PCR ELISA detected highest expression of PLEKHG5 in ovary. Abundant expression was also detected in heart, brain, lung, kidney, and testis, and moderate expression was present in spleen, pancreas, skeletal muscle, and liver.
Using transiently transfected HEK293 and MCF10A cell lines, Maystadt et al. (2007) found that PLEKHG5 activates the nuclear factor kappa-B (NFKB1) signaling pathway. Immunofluorescence analysis showed that PLEKHG5 protein is localized diffusely to cytoplasm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Domain Containing Family G, Member 5 (PLEKHG5) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3."Oncogene 20:7307-7317(2001) [PubMed] [Europe PMC] [Abstract]
  7. "A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype."Mol. Biol. Cell 17:1880-1887(2006) [PubMed] [Europe PMC] [Abstract]
  8. "PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease." Hum. Mol. Genet. 22:4224-4232(2013) [PubMed] [Europe PMC] [Abstract]
  9. "The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset."Am. J. Hum. Genet. 81:67-76(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in the PLEKHG5 gene is relevant with autosomal recessive intermediate Charcot-Marie-Tooth disease."Orphanet J. Rare Dis. 8:104-104(2013) [PubMed] [Europe PMC] [Abstract]