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Telomere Maintenance 2 (TELO2)

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CLK2; hCLK2; Protein clk-2 homolog; Telomere length regulation protein TEL2 homolog

Telomere Maintenance 2 (TELO2)
CCC M785
HGNC 29099
MGI 1918968
PubMed 9734811
RGD 1305553
UniProt Q9Y4R8
Wiki TELO2
Unlike yeast Tel2, human TELO2 does not function in telomere maintenance, but has a critical role in checkpoint responses to cellular stress. human TEL2 appeared to have no function in telomere maintenance. Conditional deletion of Tel2 from mouse embryonic fibroblasts compromised their response to ionizing and ultraviolet radiation by diminishing activation of checkpoint kinases and their downstream effectors. While Tel2 deletion did not alter PIKK mRNA levels, in vivo pulse labeling experiments showed that Tel2 controlled the stability of Atm and Mtor. Each of the PIKK family members associated with mouse and human TEL2 in vivo, and in vitro experiments showed that TEL2 bound to part of the HEAT repeat segments of human ATM and rat Mtor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomere Maintenance 2 (TELO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomere Maintenance 2 (TELO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomere Maintenance 2 (TELO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomere Maintenance 2 (TELO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomere Maintenance 2 (TELO2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomere Maintenance 2 (TELO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomere Maintenance 2 (TELO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomere Maintenance 2 (TELO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomere Maintenance 2 (TELO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomere Maintenance 2 (TELO2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomere Maintenance 2 (TELO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomere Maintenance 2 (TELO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomere Maintenance 2 (TELO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomere Maintenance 2 (TELO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomere Maintenance 2 (TELO2) ELISA Kit Customized Service Offer
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  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability."Genes Dev. 24:1939-1950(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."Genes Dev. 24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly."J. Biol. Chem. 285:20109-20116(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response."J. Clin. Invest. 122:2827-2836(2012) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "SCF(Fbxo9) and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma."Nat. Cell Biol. 15:72-81(2013) [PubMed] [Europe PMC] [Abstract]