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Ankyrin Repeat Domain Protein 28 (ANKRD28)

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PITK; PP6-ARS-A; Phosphatase Interactor Targeting K Protein; Protein Phosphatase 6 Ankyrin Repeat A; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

Ankyrin Repeat Domain Protein 28 (ANKRD28)
CCC M776
HGNC 29024
MGI 2145661
PubMed 21760593
RGD 1559931
UniProt O15084
ANKRD28 selectively inhibited the phosphorylase activity of PP1C in a dose-dependent manner. Phosphorylation of ser1013 and ser1017, which lie within the putative PP1-binding motif, negatively regulated ANKRD28 binding to PP1C. Immunoprecipitation studies showed that ANKRD28 bound to hnRNP-K .
ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284, an effect that was enhanced in vivo by an S1013A/S1017A double mutant, suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284. Microarray analysis found that expression of ANKRD28 resulted in altered expression of 47 genes, including marked induction of MEK5 (MAP2K5).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Domain Protein 28 (ANKRD28) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Domain Protein 28 (ANKRD28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Domain Protein 28 (ANKRD28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Domain Protein 28 (ANKRD28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Domain Protein 28 (ANKRD28) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Domain Protein 28 (ANKRD28) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Domain Protein 28 (ANKRD28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Domain Protein 28 (ANKRD28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Domain Protein 28 (ANKRD28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Domain Protein 28 (ANKRD28) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Domain Protein 28 (ANKRD28) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Domain Protein 28 (ANKRD28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Domain Protein 28 (ANKRD28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Domain Protein 28 (ANKRD28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Domain Protein 28 (ANKRD28) ELISA Kit Customized Service Offer
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  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
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  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]