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Lin-9 Homolog (LIN9)

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TGS; BARA; TUDOR Gene Similar; Rb Related Pathway Actor; Beta subunit-associated regulator of apoptosis; Type I interferon receptor beta chain-associated protein

Lin-9 Homolog (LIN9)
CCC M753
HGNC 30830
MGI 1919818
PubMed 23667535
RGD 1591104
UniProt Q5TKA1
Wiki LIN9
LIN9 encodes a 542-amino acid protein that contains 2 regions highly conserved between C. elegans Lin9 and 2 Drosophila orthologs. Immunoprecipitation experiments with GST fusion proteins showed that LIN9 binds via its amino-terminal portion to RB protein both in vitro and in vivo. Coexpression of LIN9 with RB protein in Saos-2 cells enhanced the formation of flat (senescent-like) cells.
Transactivation assays with a panel of incompletely penetrant RB mutants demonstrated that LIN9 enhances RB-dependent transactivation. LIN9 inhibited oncogenic transformation of mouse fibroblasts in an RB-dependent manner, and that inactivation of LIN9 substituted for inactivation of RB protein in the transformation of human fibroblasts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-9 Homolog (LIN9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-9 Homolog (LIN9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-9 Homolog (LIN9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-9 Homolog (LIN9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-9 Homolog (LIN9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-9 Homolog (LIN9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-9 Homolog (LIN9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-9 Homolog (LIN9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-9 Homolog (LIN9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-9 Homolog (LIN9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-9 Homolog (LIN9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-9 Homolog (LIN9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-9 Homolog (LIN9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-9 Homolog (LIN9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-9 Homolog (LIN9) ELISA Kit Customized Service Offer
  1. "Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein."EMBO J. 23:4627-4638(2004) [PubMed] [Europe PMC] [Abstract]
  2. "A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes."Exp. Cell Res. 312:2465-2475(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]