Triggering Receptor Expressed On Myeloid Cells Like Protein 3 (TREML3)

TREML3 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, but it has distinct structural and functional properties.

all genes in the TREM cluster have an exon encoding the 5-prime UTR and leader peptide, a second exon encoding the IgV domain, and a variable number of downstream exons encoding the stalk, transmembrane, and cytoplasmic regions. TLT3 contains 5 exons. Unlike other members of the TREM cluster, the stalk region of TLT3 is split across 2 exons.The 165-amino acid protein has a calculated molecular mass of 18 kD. It contains an IgV domain, a transmembrane domain with a charged lys residue, and a cytoplasmic domain.