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SAP30 Binding Protein (SAP30BP)

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HCNGP; HTRG; HTRP; Transcriptional regulator protein HCNGP

SAP30 Binding Protein (SAP30BP)
CCC M746
HGNC 30785
MGI 1927479
PubMed 19223330
RGD 1565537
UniProt Q9UHR5
The deduced 308-amino acid protein contains a bipartite nuclear localization signal and an LXXXIXXL motif similar to a motif in nuclear receptor corepressor N-CoR (NCOR1). By Northern blot analysis, they detected a 1,350-nucleotide transcript in human embryo fibroblasts infected with HSV-1 but absent from uninfected fibroblasts, and they detected HTRP mRNA in human brain, heart, liver, lung, spleen, and kidney.
Further analysis of HTRP deletion mutants showed that the N-terminal domain prior to amino acid 225 is responsible for specific HTRP-SAP30 binding. In vitro GST pull-down assays and in vivo immunoprecipitation showed that HTRP interacted with at least 3 proteins including SAP30; however, the identity of the additional 2 proteins was not determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SAP30 Binding Protein (SAP30BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SAP30 Binding Protein (SAP30BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SAP30 Binding Protein (SAP30BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SAP30 Binding Protein (SAP30BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for SAP30 Binding Protein (SAP30BP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SAP30 Binding Protein (SAP30BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SAP30 Binding Protein (SAP30BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SAP30 Binding Protein (SAP30BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SAP30 Binding Protein (SAP30BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for SAP30 Binding Protein (SAP30BP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SAP30 Binding Protein (SAP30BP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SAP30 Binding Protein (SAP30BP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SAP30 Binding Protein (SAP30BP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SAP30 Binding Protein (SAP30BP) CLIA Kit Customized Service Offer
n/a ELISA Kit for SAP30 Binding Protein (SAP30BP) ELISA Kit Customized Service Offer
  1. "HTRP -- an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors."J. Biochem. 136:169-176(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract], Pancreas, Skin and Uterus.
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]