≡

SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4)

[Edit]

SSB-4; SPRY domain-containing SOCS box protein 4

SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4)
CCC M723
HGNC 30630
MGI 2183445
PubMed 20561531
RGD 1562307
UniProt Q96A44
By database analysis, Wang et al. (2005) identified SPSB4, which they called SSB4. The deduced 273-amino acid protein shares 75% amino acid identity with SPSB1. SPSB4 contains a central SPRY domain and a C-terminal SOCS box. Coimmunoprecipitation studies showed that SPSB4 interacted with MET . The International Radiation Hybrid Mapping Consortium mapped the SPSB4 gene to chromosome 3 .
However, siRNA knockdown of SPSB1 repressed HGF-induced reporter gene expression and also suppressed Elk1 activation. Mutation analysis showed that SPSB1 was phosphorylated at tyr31 upon HGF stimulation, and tyr31-phosphorylated SPSB1 interacted with p120-RASGAP (RASA1) specifically in response to HGF stimulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 4 (SPSB4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases."Genes Dev. 18:3055-3065(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway."J. Biol. Chem. 280:16393-16401(2005) [PubMed] [Europe PMC] [Abstract]