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Spire Homolog 1 (SPIRE1)

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SPIR1

Spire Homolog 1 (SPIRE1)
CCC M720
HGNC 30622
MGI 1915416
PubMed 24213528
RGD 1305892
UniProt Q08AE8
Spire proteins, such as SPIRE1, are highly conserved between species. In vitro, Spire nucleated new filaments at a rate that is similar to that of the formin family of proteins (FMN1) but slower than in the activated Arp2/3 complex , and it remained associated with the slow-growing pointed end of the new filament. Spire contains a cluster of 4 WASP homology 2 (WH2) domains, each of which binds an actin monomer. Maximal nucleation activity requires all 4 WH2 domains along with an additional acting-binding motif, conserved among Spire proteins. Spire itself is conserved among metazoans and, together with the formin Cappuccino , is required for axis specification in oocytes and embryos, suggesting that multiple actin nucleation factors collaborate to construct essential cytoskeletal structures.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spire Homolog 1 (SPIRE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spire Homolog 1 (SPIRE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spire Homolog 1 (SPIRE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spire Homolog 1 (SPIRE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spire Homolog 1 (SPIRE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spire Homolog 1 (SPIRE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spire Homolog 1 (SPIRE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spire Homolog 1 (SPIRE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spire Homolog 1 (SPIRE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spire Homolog 1 (SPIRE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spire Homolog 1 (SPIRE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spire Homolog 1 (SPIRE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spire Homolog 1 (SPIRE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spire Homolog 1 (SPIRE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spire Homolog 1 (SPIRE1) ELISA Kit Customized Service Offer
  1. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract].
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  7. "The Spir actin organizers are involved in vesicle transport processes."Curr. Biol. 11:1963-1968(2001) [PubMed] [Europe PMC] [Abstract] and Testis.
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division."Curr. Biol. 21:955-960(2011) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain (KIND)*formin-2 formin SPIR interaction motif (FSI) complex."J. Biol. Chem. 286:30732-30739(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structure and function of the interacting domains of Spire and Fmn-family formins."Proc. Natl. Acad. Sci. U.S.A. 108:11884-11889(2011) [PubMed] [Europe PMC] [Abstract]