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DNA Damage Inducible Transcript 4 Like Protein (DDIT4L)

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REDD2; Rtp801L; Regulated In Development And DNA Damage Response 2; Similar To Smhs1 Protein; HIF-1 responsive protein RTP801-like

DNA Damage Inducible Transcript 4 Like Protein (DDIT4L)
CCC M713
HGNC 30555
MGI 1920534
RGD 619738
UniProt Q96D03
Ellisen et al. (2002) identified REDD1 as a transcriptional target of p53 induced following DNA damage. They also identified a related human transcript that encodes a protein with 50% overall identity to REDD1, which they termed REDD2. Expression of REDD2 was only detectable by RT-PCR.
Reiling and Hafen (2004) found that simultaneous loss of Drosophila scylla and charybdis, which are homologs of the human REDD1 and REDD2 genes, generated flies that were more susceptible to hypoxia and that showed mild overgrowth. Conversely, overactivation of scylla and charybdis reduced growth. The authors showed that scylla and charybdis were induced by hypoxia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Inducible Transcript 4 Like Protein (DDIT4L) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species."Mol. Cell 10:995-1005(2002) [PubMed] [Europe PMC] [Abstract]
  5. "REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death."Arterioscler. Thromb. Vasc. Biol. 24:1830-1835(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex."Genes Dev. 18:2893-2904(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway."J. Biol. Chem. 280:9769-9772(2005) [PubMed] [Europe PMC] [Abstract]