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Membrane Associated Ring Finger Protein 6 (MARCH6)

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TEB4; MARCH-VI; RNF176; Doa10 homolog; Membrane-associated RING-CH protein VI; RING finger protein 176; E3 ubiquitin-protein ligase MARCH6

Membrane Associated Ring Finger Protein 6 (MARCH6)
CCC M711
HGNC 30550
MGI 2442773
PubMed 16373356
RGD 1565757
UniProt O60337
Wiki MARCH6
MARCH6 is an E3 ubiquitin ligase that localizes to endoplasmic reticulum (ER) membranes.The deduced protein contains 971 amino acids and is identical to a previously reported protein, TEB4. TEB4 orthologs from several species share highest homology in their unconventional C4HC3 RING domains and TD domains. Hydropathy analysis of TEB4 suggested that it contains 13 transmembrane regions, with the N-terminal RING domain facing the cytoplasm and the C-terminal domain facing the ER lumen. Immunofluorescence analysis showed that epitope-tagged TEB4 colocalized with an ER resident marker in transfected HeLa cells. Western blot analysis of human brain lysates showed that TEB4 had an apparent molecular mass of 97 kD. In vitro-translated TEB4 associated with microsomes

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 6 (MARCH6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 6 (MARCH6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 6 (MARCH6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 6 (MARCH6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 6 (MARCH6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 6 (MARCH6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 6 (MARCH6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 6 (MARCH6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 6 (MARCH6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 6 (MARCH6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 6 (MARCH6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 6 (MARCH6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 6 (MARCH6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 6 (MARCH6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 6 (MARCH6) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation."Genes Dev. 15:2660-2674(2001) [PubMed] [Europe PMC] [Abstract]
  6. "TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum."Biochem. J. 388:647-655(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)."J. Biol. Chem. 281:4646-4653(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase."Mol. Cell. Biol. 29:5339-5347(2009) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]