≡

EEN Binding Protein (EBP)

[Edit]

SH3D19; EVE1; Kryn; SH3P19; SH3 Domain Containing 19; ADAM-binding protein Eve-1

EEN Binding Protein (EBP)
CCC M703
HGNC 30418
MGI 1350923
PubMed 21689417
RGD 1304885
UniProt Q5HYK7
The deduced 767-amino acid protein has a central proline-rich region and 4 C-terminal SH3 domains. PCR analysis detected EBP expression in all adult and fetal tissues examined. Epitope-tagged EBP was evenly distributed in the cytoplasm of transfected HeLa cells.
EBP was recruited to the nucleus by the chimeric MLL-EEN fusion protein. The SH3 domains of EBP interacted with SOS2, but not SOS1, and that the EBP-EEN and EBP-SOS2 interactions occurred simultaneously. Coexpression of EBP with EEN in rat embryonic fibroblasts led to suppression of RAS -induced cellular transformation and RAS-mediated activation of ELK1 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EEN Binding Protein (EBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EEN Binding Protein (EBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EEN Binding Protein (EBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EEN Binding Protein (EBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for EEN Binding Protein (EBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EEN Binding Protein (EBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EEN Binding Protein (EBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EEN Binding Protein (EBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EEN Binding Protein (EBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for EEN Binding Protein (EBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EEN Binding Protein (EBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EEN Binding Protein (EBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EEN Binding Protein (EBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EEN Binding Protein (EBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for EEN Binding Protein (EBP) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein."Blood 103:1445-1453(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands."J. Biol. Chem. 279:41950-41959(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]