≡

SET Domain Containing Protein 7 (SETD7)

[Edit]

SET7; SET7/9; Set9; KMT7; Lysine N-methyltransferase 7; Histone H3-K4 methyltransferase SETD7; Histone-lysine N-methyltransferase SETD7

SET Domain Containing Protein 7 (SETD7)
CCC M701
HGNC 30412
MGI 1920501
PubMed 21855806
RGD 1586346
UniProt Q8WTS6
Wiki SETD7
Methylation of histone H3 at lysine-9 (K9) by SUV39H1 and the subsequent recruitment of heterochromatin protein-1 (HP1) is linked to gene silencing. In addition to K9, H3 methylation also occurs at K4, K27, and K36.
SET7 methylates H3-K4 in vitro and in vivo and that methylation of H3-K4 and methylation of H3-K9 inhibit each other. Furthermore, H3-K4 methylation and H3-K9 methylation by SET7 and SUV39H1, respectively, were found to have differential effects on subsequent histone acetylation by p300. This study provided a molecular explanation to the differential effects of H3-K4 and H3-K9 methylation on transcription.Set9 regulates the expression of p53 target genes in a manner dependent on the p53 methylation site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM701Hu01 Recombinant SET Domain Containing Protein 7 (SETD7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM701Hu21 Monoclonal Antibody to SET Domain Containing Protein 7 (SETD7) WB; IHC; ICC; IP.
PAM701Hu01 Polyclonal Antibody to SET Domain Containing Protein 7 (SETD7) WB; IHC; ICC; IP.
Assay Kits SEM701Hu ELISA Kit for SET Domain Containing Protein 7 (SETD7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Domain Containing Protein 7 (SETD7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Domain Containing Protein 7 (SETD7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Domain Containing Protein 7 (SETD7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Domain Containing Protein 7 (SETD7) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Domain Containing Protein 7 (SETD7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Domain Containing Protein 7 (SETD7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Domain Containing Protein 7 (SETD7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Domain Containing Protein 7 (SETD7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Domain Containing Protein 7 (SETD7) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Domain Containing Protein 7 (SETD7) ELISA Kit Customized Service Offer
  1. "Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase."Mol. Cell 8:1207-1217(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation."Genes Dev. 16:479-489(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cascade of distinct histone modifications during collagenase gene activation."Mol. Cell. Biol. 23:1808-1816(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Gene-specific modulation of TAF10 function by SET9-mediated methylation."Mol. Cell 14:175-182(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription."J. Biol. Chem. 280:36244-36253(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Repression of p53 activity by Smyd2-mediated methylation."Nature 444:629-632(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Catalytic mechanism and product specificity of the histone lysine methyltransferase SET7/9: an ab initio QM/MM-FE study with multiple initial structures."J. Am. Chem. Soc. 128:1272-1278(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure and functional analysis of the histone methyltransferase SET7/9."Cell 111:105-115(2002) [PubMed] [Europe PMC] [Abstract]
  14. "The active site of the SET domain is constructed on a knot."Nat. Struct. Biol. 9:833-838(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Structure and catalytic mechanism of the human histone methyltransferase SET7/9."Nature 421:652-656(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet."EMBO J. 22:292-303(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Regulation of p53 activity through lysine methylation."Nature 432:353-360(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for the methylation site specificity of SET7/9."Nat. Struct. Mol. Biol. 13:140-146(2006) [PubMed] [Europe PMC] [Abstract]