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SEH1 Like Protein (SEH1L)

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SEH1A; SEH1B; Seh1; SEC13L; Sec13 Like Protein; Nucleoporin Seh1; Nup107-160 subcomplex subunit SEH1

SEH1 Like Protein (SEH1L)
CCC M698
HGNC 30379
MGI 1919374
PubMed 20824097
UniProt Q96EE3
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and SEH1L is part of one such subcomplex, Nup107-160.SEH1L shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13.
SEH1L was loosely associated with the Nup107-160 complex biochemically. SEH1L depletion by RNA interference led to phenotypes similar to knockdown of other constituents of this complex, including delocalization of some nucleoporins from the nuclear envelope. All constituents of the Nup107-160 complex, including SEH1L, were targeted to kinetochores from prophase to anaphase during mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEH1 Like Protein (SEH1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEH1 Like Protein (SEH1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEH1 Like Protein (SEH1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEH1 Like Protein (SEH1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEH1 Like Protein (SEH1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEH1 Like Protein (SEH1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEH1 Like Protein (SEH1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEH1 Like Protein (SEH1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEH1 Like Protein (SEH1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEH1 Like Protein (SEH1L) ELISA Kit Customized Service Offer
  1. "Proteomic analysis of the mammalian nuclear pore complex."J. Cell Biol. 158:915-927(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis."Mol. Biol. Cell 15:3333-3344(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions."EMBO J. 26:1853-1864(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex."Proc. Natl. Acad. Sci. U.S.A. 104:3811-3816(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."Science 340:1100-1106(2013) [PubMed] [Europe PMC] [Abstract]