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WD Repeat Containing Domain Protein 61 (WDR61)

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REC14; SKI8; Meiotic recombination REC14 protein homolog

WD Repeat Containing Domain Protein 61 (WDR61)
CCC M684
HGNC 30300
MGI 1917493
RGD 1308228
UniProt Q9GZS3
WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance.Zhu et al. (2005) purified WDR61 from a 600-kD PAF complex and from a 400-kD SKI complex in HeLa cell nuclear extracts.
Zhu et al. (2005) determined that the human PAF and SKI complexes interact. SKI8 RNA interference showed that SKI8 was required for PAF-dependent mono- and trimethylation of histone H3 at lys4 (H3-K4) and dimethylation of H3-K79, but not dimethylation of H3-K36.The International Radiation Hybrid Mapping Consortium mapped the WDR61 gene to chromosome 15.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 61 (WDR61) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 61 (WDR61) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 61 (WDR61) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 61 (WDR61) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 61 (WDR61) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 61 (WDR61) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 61 (WDR61) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 61 (WDR61) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 61 (WDR61) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 61 (WDR61) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 61 (WDR61) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 61 (WDR61) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 61 (WDR61) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 61 (WDR61) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 61 (WDR61) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The human PAF complex coordinates transcription with events downstream of RNA synthesis."Genes Dev. 19:1668-1673(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation."Genes Dev. 23:2765-2777(2009) [PubMed] [Europe PMC] [Abstract]
  7. "The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS."Cell 140:491-503(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure and function of WD40 domain proteins."Protein Cell 2:202-214(2011) [PubMed] [Europe PMC] [Abstract]