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Regulatory Associated Protein Of mTOR (RPTOR)

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KOG1; Mip1; Raptor; p150 target of rapamycin (TOR)-scaffold protein

Regulatory Associated Protein Of mTOR (RPTOR)
CCC M681
HGNC 30287
MGI 1921620
PubMed 21060808
RGD 1311784
UniProt Q8N122
Wiki RPTOR
RPTOR encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.RAPTOR has a positive role in nutrient-stimulated signaling to the downstream effector S6K1, maintenance of cell size, and MTOR protein expression. The association of RAPTOR with MTOR also negatively regulates the MTOR kinase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM681Hu01 Recombinant Regulatory Associated Protein Of mTOR (RPTOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Regulatory Associated Protein Of mTOR (RPTOR) Monoclonal Antibody Customized Service Offer
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Assay Kits n/a CLIA Kit for Regulatory Associated Protein Of mTOR (RPTOR) CLIA Kit Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Associated Protein Of mTOR (RPTOR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Associated Protein Of mTOR (RPTOR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Associated Protein Of mTOR (RPTOR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Associated Protein Of mTOR (RPTOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Associated Protein Of mTOR (RPTOR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Associated Protein Of mTOR (RPTOR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Associated Protein Of mTOR (RPTOR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Associated Protein Of mTOR (RPTOR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Associated Protein Of mTOR (RPTOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Associated Protein Of mTOR (RPTOR) ELISA Kit Customized Service Offer
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  7. "Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control."Mol. Cell 10:457-468(2002) [PubMed] [Europe PMC] [Abstract]
  8. "TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function."Curr. Biol. 13:797-806(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function."Genes Cells 9:359-366(2004) [PubMed] [Europe PMC] [Abstract]
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  13. "Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation."Curr. Biol. 18:1269-1277(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  15. "AMPK phosphorylation of raptor mediates a metabolic checkpoint."Mol. Cell 30:214-226(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy."Mol. Biol. Cell 20:1981-1991(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids."Cell 141:290-303(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation."J. Biol. Chem. 285:80-94(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  27. "5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia."EMBO Mol. Med. 4:1043-1056(2012) [PubMed] [Europe PMC] [Abstract]
  28. "Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation."J. Biol. Chem. 287:18398-18407(2012) [PubMed] [Europe PMC] [Abstract]
  29. "Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells."Cell 154:859-874(2013) [PubMed] [Europe PMC] [Abstract]
  30. "PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription."FEBS Lett. 587:3303-3308(2013) [PubMed] [Europe PMC] [Abstract]
  31. "The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex."Hum. Mol. Genet. 22:4031-4042(2013) [PubMed] [Europe PMC] [Abstract]
  32. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]