Cytochrome b-561 Domain Containing Protein 2 (CYB561D2)

CYB561D2 is associated with a putative lung cancer tumor suppressor gene. The deduced 222-amino acid integral protein is 95% identical to the mouse protein and contains 6 transmembrane helices with both N and C termini in the cytoplasm. Northern blot analysis revealed wide expression of a 1.5-kb transcript that was strongest in liver, followed by placenta and lung, with low amounts in heart, kidney, and pancreas and only traces in skeletal muscle and brain.

CYB561D2 was highly expressed in most lung cancer cell lines tested. No mutations were detected in any of the lung cancer cell lines. CYB561D2 is an unlikely candidate tumor suppressor gene.CYB561D2 gene contains 4 exons and spans 3.2 kb.