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TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL)

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TIP; Type 2A-interacting protein; Putative MAPK-activating protein PM10

TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL)
CCC M672
HGNC 30231
MGI 1915087
PubMed 23892082
RGD 1310442
UniProt O75663
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A), PP4 , and PP6. TIP isoform-2 did not interact with PP2A, suggesting that the C terminus of TIP is important for PP2A binding. Incubation of PP2A with TIP, but not TIP isoform-2, resulted in dose-dependent inhibition of PP2A phosphatase activity. Cells in which TIP was depleted by small interfering RNA exhibited decreased phosphorylation of a 32-kD substrate of ATM/ATR kinases.
TIP is an inhibitory regulator of PP2A and that the TIP/PP2A complex has a role within the ATM/ATR signaling pathway controlling DNA replication and repair.The predicted protein contains 272 amino acids. Immunoblot analysis showed ubiquitous expression of a 33-kD TIP protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) CLIA Kit Customized Service Offer
n/a ELISA Kit for TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) CLIA Kit Customized Service Offer
n/a ELISA Kit for TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) CLIA Kit Customized Service Offer
n/a ELISA Kit for TIP41, TOR Signaling Pathway Regulator Like Protein (TIPRL) ELISA Kit Customized Service Offer
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