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G Antigen 2B (GAGE2B)

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CT4.2; GAGE2C; Cancer/testis antigen 4.2

G Antigen 2B (GAGE2B)
CCC M643
HGNC 31957
UniProt Q13066
GAGE cancer/testis antigens, including GAGE2B, are frequently expressed in many different types of cancer, whereas their expression in normal tissues is limited to the germ cells of the immune-privileged organs, testis and ovary.The promoters, which are highly conserved within 1.4- to 1.5-kb of the transcription initiation site, are GC-rich and have no TATA boxes. GAGE transcripts are found only in primates.
Gjerstorff and Ditzel (2008) stated that the GAGE2B gene is contained within a 9.5-kb GAGE repeat. The GAGE2B gene contains 5 exons spanning about 6.3 kb and has a LINE insertion.By genomic sequence analysis, Gjerstorff and Ditzel (2008) mapped the GAGE2B gene to a GAGE gene cluster on chromosome Xp11.23.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Antigen 2B (GAGE2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Antigen 2B (GAGE2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Antigen 2B (GAGE2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Antigen 2B (GAGE2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Antigen 2B (GAGE2B) ELISA Kit Customized Service Offer
  1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]