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Tripartite Motif Containing Protein 72 (TRIM72)

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MG53; Mitsugumin 53-KD

Tripartite Motif Containing Protein 72 (TRIM72)
CCC M636
HGNC 32671
MGI 3612190
PubMed 24487118
RGD 1562778
UniProt Q6ZMU5
Both the mouse and human proteins contain 477 amino acids and have an N-terminal tripartite motif consisting of RING, B-box, and coiled-coil domains, followed by a C-terminal SPRY domain.
Fluorescence-tagged Mg53 and endogenous Mg53 localized to the sarcolemmal membrane and intracellular vesicles of mouse skeletal muscle.Scrape-wounding of C2C12 cells resulted in dense accumulation of fluorescence-tagged Mg53 at the site of membrane damage, and this accumulation required Mg53 oligomerization and was associated with nucleation of vesicles into a membrane patch. Oligomerization of Mg53 required oxidation of cys242, and interaction of Mg53 with phosphatidylserine mediated recruitment of vesicles to sites of injury. .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 72 (TRIM72) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 72 (TRIM72) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 72 (TRIM72) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 72 (TRIM72) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 72 (TRIM72) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 72 (TRIM72) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 72 (TRIM72) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 72 (TRIM72) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 72 (TRIM72) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 72 (TRIM72) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 72 (TRIM72) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 72 (TRIM72) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 72 (TRIM72) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 72 (TRIM72) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 72 (TRIM72) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] and Thymus.
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  4. "S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death."J. Mol. Cell. Cardiol. 69:67-74(2014) [PubMed] [Europe PMC] [Abstract]
  5. "Crystal structure of PRY-SPRY domain of human TRIM72."Proteins 78:790-795(2010) [PubMed] [Europe PMC] [Abstract]