RANBP2 Like And GRIP Domain Containing Protein 2 (RGPD2)

By searching databases for intrachromosomal duplications of genes in primates but not in other metazoans, Ciccarelli et al. (2005) identified 8 RGPD genes, including RGPD2, which they called RGP2. The RGPD genes resulted from duplications of a region of human chromosome 2 containing the RANBP2 and GCC2 genes.

Like other RGPD proteins, the deduced RGPD2 protein exceeds 1,700 amino acids. Most of the sequence is homologous to regions of RANBP2, except for the C terminus, which includes the GRIP domain from GCC2. Using primers that did not differentiate between RGPD1 and RGPD2 for PCR analysis, Ciccarelli et al. (2005) detected expression in testis and HeLa cell cDNA libraries.RGPD2 is the more centromeric of the 2 RGPD genes on chromosome 2p11.2.