Synleurin (SLRN)

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LRRC70; Leucine Rich Repeat Containing 70

Synleurin (SLRN)
A novel single span transmembrane leucine-rich repeat protein, synleurin, that renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS). The major part of the extracellular domain consists of a leucine-rich repeats (LRR) cassette. The LRR central core has 12 analogous LRR repeating modules arranged in a seamless tandem array. The LRRs are most homologous to that of chondroadherin, insulin-like growth factor binding proteins, platelet glycoprotein V, slits, and toll-like receptors. Synleurin expression was detected at low levels in many tissues, including smooth muscle, brain, uterus, pancreas, cartilage, adipose, spleen, and testis. When synleurin is ecotopically expressed in transfected cells, the cells exhibit amplified responses to bFGF, EGF, PDGF-B, IGF-1, IGF-2, and LPS. Synleurin gene (slrn) maps to human chromosome at 5q12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synleurin (SLRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synleurin (SLRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synleurin (SLRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synleurin (SLRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synleurin (SLRN) ELISA Kit Customized Service Offer
  1. "Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses."Biochem. Biophys. Res. Commun. 305:981-988(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]