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PCF11 Homolog (PCF11)

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Pre-mRNA cleavage complex 2 protein Pcf11

PCF11 Homolog (PCF11)
CCC M567
HGNC 30097
MGI 1919579
PubMed 24004414
RGD 1563397
UniProt O94913
De Vries et al. (2000) purified pre-mRNA cleavage factor IIm (CFIIm) of the 3-prime end processing complex from HeLa cell nuclear extracts and determined that it contains PCF11 and CLP1.The deduced protein contains 1,644 amino acids. RT-PCR ELISA detected intermediate expression in all adult and fetal tissues and all specific brain regions examined.The C-terminal domain motif of ser2-pro3-thr4-ser5 forms a beta turn that binds to a conserved groove in the C-terminal domain-interacting domain of PCF11. The ser2 phosphate group does not make direct contact with PCF11, but may be recognized indirectly because it stabilizes the beta turn with an additional hydrogen bond. Iteration of the peptide structure results in a compact beta spiral model of the C-terminal domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PCF11 Homolog (PCF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PCF11 Homolog (PCF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PCF11 Homolog (PCF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PCF11 Homolog (PCF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for PCF11 Homolog (PCF11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PCF11 Homolog (PCF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PCF11 Homolog (PCF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PCF11 Homolog (PCF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PCF11 Homolog (PCF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for PCF11 Homolog (PCF11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PCF11 Homolog (PCF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PCF11 Homolog (PCF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PCF11 Homolog (PCF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PCF11 Homolog (PCF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for PCF11 Homolog (PCF11) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
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  3. "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors."EMBO J. 19:5895-5904(2000) [PubMed] [Europe PMC] [Abstract]
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]