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Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1)

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MADP1; RBM36; ZCCHC19; U11/U12 small nuclear ribonucleoprotein 31 kDa protein

Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1)
CCC M548
HGNC 29620
MGI 1914447
RGD 1309851
UniProt Q8TBF4
ZCRB1 contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing.
The deduced 217-amino acid protein contains an RNA-binding motif, a CCHC-type zinc finger motif, and lysine- and glutamine-rich sequences. Database analysis suggested that ZCRB1 is conserved from plant to primate. Northern blot analysis of mouse tissues detected highest expression in heart and testis, lower expression in cerebellum, hindbrain, muscle, lung, and fat, and lowest expression in liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, CCHC-Type And RNA Binding Motif 1 (ZCRB1) ELISA Kit Customized Service Offer
  1. "Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12."Genomics 89:59-69(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of RNA binding domain in zinc finger CCHC-type and RNA binding motif 1."Submitted (JUN-2007) to the PDB data bank