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Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9)

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MADHIP; SMADIP; SARA; MAD; NSP; Mothers Against Decapentaplegic Homolog(Drosophila)Interacting Protein; Receptor Activation Anchor; Novel serine protease

Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9)
CCC M531
HGNC 6775
MGI 2652838
PubMed 22819827
RGD 1310856
UniProt O95405
ZFYVE9 encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 9 (ZFYVE9) ELISA Kit Customized Service Offer
  1. "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor."Cell 95:779-791(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel serine protease-like molecule in human brain."Brain Res. Mol. Brain Res. 55:181-197(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Early endosomal regulation of Smad-dependent signaling in endothelial cells."J. Biol. Chem. 277:18046-18052(2002) [PubMed] [Europe PMC] [Abstract]
  6. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cytoplasmic PML function in TGF-beta signalling."Nature 431:205-211(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis of Smad2 recognition by the Smad anchor for receptor activation."Science 287:92-97(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control."Genes Dev. 16:1950-1963(2002) [PubMed] [Europe PMC] [Abstract]