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FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1)

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ZFYVE7; Zinc finger FYVE domain-containing protein 7

FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1)
CCC M527
HGNC 14673
MGI 107277
PubMed 20100911
RGD 1309069
UniProt Q9BQS8
FYCO1 gene consists of 18 exons and has a genomic size of 77.8 kb, with a structure typical of other human genes with a large first intron (10.7 kb).
The cDNA was 8500 bp long with an open reading frame (ORF) of 4434 bp encoding a deduced 1478-amino acid protein, with a predicted molecular mass of 167 kD. Northern blot analysis revealed an 8.5-kb transcript, which is expressed mainly in heart and skeletal muscle. The FYCO1 protein was predicted to contain a FYVE zinc finger domain, a RUN domain involved in Ras-like GTPase signaling, and multiple coiled-coil domains. The STRL33 gene was localized within the fourteenth intron of the FYCO1 gene, with an antiparallel transcription orientation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FYVE And Coiled Coil Domain Containing Protein 1 (FYCO1) ELISA Kit Customized Service Offer
  1. "The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3."Eur. J. Hum. Genet. 10:52-61(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport."J. Cell Biol. 188:253-269(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in FYCO1 cause autosomal-recessive congenital cataracts."Am. J. Hum. Genet. 88:827-838(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]