≡

AlkB, Alkylation Repair Homolog 1 (ALKBH1)

[Edit]

ABH; hABH; alkB; DNA oxidative demethylase ALKBH1; Alpha-ketoglutarate-dependent dioxygenase ABH1; Alkylated DNA repair protein alkB homolog 1

AlkB, Alkylation Repair Homolog 1 (ALKBH1)
CCC M500
HGNC 17911
MGI 2384034
PubMed 21072209
UniProt Q13686
The ABH cDNA encodes a deduced 299-amino acid protein that is 52% similar and 23% identical to AlkB. Northern blot analysis revealed ubiquitous expression of a 2.1-kb ABH transcript. SDS-PAGE analysis showed that ABH was expressed as a 34-kD protein.
The deduced 389-amino acid protein has a C-terminal AlkB homology domain that is predicted to function as a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. Quantitative real-time PCR detected ABH1 expression in all 16 tissues examined, with highest expression in spleen, followed by pancreas and placenta. Fluorescence-tagged ABH1 was expressed predominantly in the nucleus of transfected HeLa cells, with weaker cytoplasmic staining.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 1 (ALKBH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 1 (ALKBH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 1 (ALKBH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 1 (ALKBH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 1 (ALKBH1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 1 (ALKBH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 1 (ALKBH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 1 (ALKBH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 1 (ALKBH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 1 (ALKBH1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair."Nucleic Acids Res. 24:931-937(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression and sub-cellular localization of human ABH family molecules."J. Cell. Mol. Med. 11:1105-1116(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA."J. Biol. Chem. 283:25046-25056(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites."DNA Repair 9:58-65(2010) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]