AlkB, Alkylation Repair Homolog 3 (ALKBH3)

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DEPC-1; ABH3; Alkylated DNA repair protein alkB homolog 3; Prostate cancer antigen 1; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

AlkB, Alkylation Repair Homolog 3 (ALKBH3)
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine.The deduced protein shares 23.1% amino acid identity over the core region with E. coli AlkB and shares similarity to alpha-ketoglutarate/Fe(II)-dependent dioxygenases in the C-terminal region. It has a predicted tertiary structure with high similarity to the crystal structure of known dioxygenases. Northern blot analysis detected ALKBH3 expression in all tissues examined, as well as several carcinoma cell lines, with highest expression in spleen, prostate, bladder and colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 3 (ALKBH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 3 (ALKBH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 3 (ALKBH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 3 (ALKBH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 3 (ALKBH3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 3 (ALKBH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 3 (ALKBH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 3 (ALKBH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 3 (ALKBH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 3 (ALKBH3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 3 (ALKBH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 3 (ALKBH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 3 (ALKBH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 3 (ALKBH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 3 (ALKBH3) ELISA Kit Customized Service Offer
  1. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Reversal of DNA alkylation damage by two human dioxygenases."Proc. Natl. Acad. Sci. U.S.A. 99:16660-16665(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA."Nature 421:859-863(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Repair of methylation damage in DNA and RNA by mammalian AlkB homologues."J. Biol. Chem. 280:39448-39459(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Expression and sub-cellular localization of human ABH family molecules."J. Cell. Mol. Med. 11:1105-1116(2007) [PubMed] [Europe PMC] [Abstract]
  7. "DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation."Mol. Cell 44:373-384(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage."EMBO J. 25:3389-3397(2006) [PubMed] [Europe PMC] [Abstract]