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AlkB, Alkylation Repair Homolog 4 (ALKBH4)

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ABH4; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

AlkB, Alkylation Repair Homolog 4 (ALKBH4)
CCC M497
HGNC 21900
MGI 1919291
PubMed 23673617
RGD 1308608
UniProt Q9NXW9
By database analysis to identify sequences similar to ABH genes, followed by PCR of a testis cDNA library, Tsujikawa et al. (2007) cloned ALKBH4, which they called ABH4. The deduced 302-amino acid protein has a C-terminal AlkB homology domain that is predicted to function as a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. Quantitative real-time PCR detected variable ABH4 expression in all 16 tissues examined, with highest expression in pancreas, ovary, and spleen. Fluorescence-tagged ABH4 was expressed in both the cytoplasm and nucleus of transfected HeLa cells.Hartz (2010) mapped the ALKBH4 gene to chromosome 7q22.1 based on an alignment of the ALKBH4 sequence with the genomic sequence (GRCh37).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 4 (ALKBH4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 4 (ALKBH4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 4 (ALKBH4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 4 (ALKBH4) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 4 (ALKBH4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 4 (ALKBH4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 4 (ALKBH4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 4 (ALKBH4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 4 (ALKBH4) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 4 (ALKBH4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 4 (ALKBH4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 4 (ALKBH4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 4 (ALKBH4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 4 (ALKBH4) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 4 (ALKBH4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression and sub-cellular localization of human ABH family molecules."J. Cell. Mol. Med. 11:1105-1116(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)-and 2-oxoglutarate-dependent decarboxylase ALKBH4."Biochem. J. 434:391-398(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Human ALKBH4 interacts with proteins associated with transcription."PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "ALKBH4-dependent demethylation of actin regulates actomyosin dynamics."Nat. Commun. 4:1832-1832(2013) [PubMed] [Europe PMC] [Abstract]