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Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1)

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AKR6A3; KCNA1B; hKvBeta3; Kvb1.3; hKvb3; K(+) channel subunit beta-1

Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1)
CCC M495
HGNC 6228
MGI 109155
PubMed 21333500
RGD 61827
UniProt Q14722
Wiki KCNAB1
KCNAB1 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. KCNA1B gene was expressed as 3.4- and 3.8-kb mRNAs in human brain. The pattern of expression of Kv1-alpha and Kv-beta subunits suggested an intricate and cell-specific regulatory mechanism that produces distinct combinations of alpha and beta subunits in different nuclei of the brain. The Kv-beta-1.1 and Kv-beta-1.2 splice variants contain an N-terminal inactivating domain similar to that found in A-type Kv channels .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily Beta 1 (KCNAb1) ELISA Kit Customized Service Offer
  1. "A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing."J. Biol. Chem. 270:28531-28534(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium."FEBS Lett. 361:13-16(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of a voltage-gated K+ channel beta subunit expressed in human heart."Proc. Natl. Acad. Sci. U.S.A. 92:6309-6313(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product."FEBS Lett. 370:32-36(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B)."Neuropharmacology 35:787-795(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits."J. Biol. Chem. 270:6272-6277(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4."J. Physiol. (Lond.) 512:325-336(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Episodic ataxia type 1 mutations in the human Kv1.1 potassium channel alter hKvbeta 1-induced N-type inactivation."J. Neurosci. 22:4786-4793(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit."J. Pharmacol. Exp. Ther. 302:545-550(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Control of human potassium channel inactivation by editing of a small mRNA hairpin."Nat. Struct. Mol. Biol. 11:950-956(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2."Eur. J. Neurosci. 24:3073-3083(2006) [PubMed] [Europe PMC] [Abstract]
  14. "NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels."Biochem. Biophys. Res. Commun. 359:269-276(2007) [PubMed] [Europe PMC] [Abstract]
  15. "The molecular basis for the actions of Kvbeta1.2 on the opening and closing of the Kv1.2 delayed rectifier channel."Channels 3:314-322(2009) [PubMed] [Europe PMC] [Abstract]