ArfGAP With GTPase, ANK Repeat And PH Domain Containing Protein 4 (AGAP4)

CTGLF1, which started as a cyclin gene, and then had three domains (PH, ArfGap and Ankyrin) contributed by insertion of a CENTG2-derived retrocopy. The mouse version of this gene, AK132782, has only a cyclin domain and represents the ancestral form before the retrocopy insertion. These observations underscore the fact that natural selection exapts novel sequence space in addition to slowly modifying existing sequence space.

PH domain can bind Phosphatidylinositol lipids within biological membranes, and proteins such as the βγ-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.