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Exosome Component 6 (EXOSC6)

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MTR3; hMtr3p; Mtr3p; EAP4; p11; mRNA Transport Regulator 3; Exosome complex component MTR3

Exosome Component 6 (EXOSC6)
CCC M481
HGNC 19055
MGI 1919794
PubMed 11719186
RGD 1309832
UniProt Q5RKV6
Wiki EXOSC6
EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart.
This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 6 (EXOSC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 6 (EXOSC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 6 (EXOSC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 6 (EXOSC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 6 (EXOSC6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 6 (EXOSC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 6 (EXOSC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 6 (EXOSC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 6 (EXOSC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 6 (EXOSC6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 6 (EXOSC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 6 (EXOSC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 6 (EXOSC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 6 (EXOSC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 6 (EXOSC6) ELISA Kit Customized Service Offer
  1. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs."Cell 107:451-464(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring."J. Mol. Biol. 323:653-663(2002) [PubMed] [Europe PMC] [Abstract]
  5. "A protein interaction framework for human mRNA degradation."Genome Res. 14:1315-1323(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Dis3-like 1: a novel exoribonuclease associated with the human exosome."EMBO J. 29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates."Cell 144:353-363(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Reconstitution, activities, and structure of the eukaryotic RNA exosome."Cell 127:1223-1237(2006) [PubMed] [Europe PMC] [Abstract]
  10. ErratumCell 131:188-189(2007)