≡

Exosome Component 10 (EXOSC10)

[Edit]

PMSCL2; PM2; PM/Scl-100; Rrp6p; RRP6; p2; p3; p4; Polymyositis/Scleroderma Autoantigen 2; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen

Exosome Component 10 (EXOSC10)
CCC M480
HGNC 9138
MGI 1355322
PubMed 15231747
UniProt Q01780
Wiki EXOSC10

Antinucleolar antibodies are found in patients with scleroderma or polymyositis or in patients with overlap of these 2 syndromes. The 2 most prominent proteins in this PMSCL autoantigen complex, PMSCL1 and PMSCL2, are detected as 75- and 100-kD molecules, respectively. The deduced 860-amino acid protein contains 2 potential N-glycosylation sites and multiple potential phosphorylation sites. Northern blot analysis revealed expression of a 2.7-kb transcript. Immunoblot analysis confirmed the identity of native and recombinant 100-kD PMSCL2 proteins.

Sequence analysis predicted that the 885-amino acid protein contains a stretch of amino acids also found in serine/threonine kinases. Epitope mapping indicated a major epitope is localized between residues 153 and 324.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 10 (EXOSC10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 10 (EXOSC10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 10 (EXOSC10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 10 (EXOSC10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 10 (EXOSC10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 10 (EXOSC10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 10 (EXOSC10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 10 (EXOSC10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 10 (EXOSC10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 10 (EXOSC10) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein."J. Exp. Med. 176:973-980(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen."J. Clin. Invest. 90:559-570(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3."Genes Immun. 2:119-127(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases."Genes Dev. 13:2148-2158(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities."Mol. Cell 12:675-687(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A protein interaction framework for human mRNA degradation."Genome Res. 14:1315-1323(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells."Mol. Cell 21:437-443(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export."Genes Dev. 21:160-174(2007) [PubMed] [Europe PMC] [Abstract]
  12. "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing."Nucleic Acids Res. 35:2564-2572(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways."RNA 13:1027-1035(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'."Genes Dev. 22:50-65(2008) [PubMed] [Europe PMC] [Abstract]
  15. "RNA exosome depletion reveals transcription upstream of active human promoters."Science 322:1851-1854(2008) [PubMed] [Europe PMC] [Abstract]
  16. "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L."EMBO J. 29:2342-2357(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Dis3-like 1: a novel exoribonuclease associated with the human exosome."EMBO J. 29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
  18. "A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination."Nucleic Acids Res. 38:8015-8026(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells."Proc. Natl. Acad. Sci. U.S.A. 107:7407-7412(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the HRDC domain of human exosome component 10."Submitted (NOV-2005) to the PDB data bank