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Exosome Component 9 (EXOSC9)

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PMSCL1; PM1; PM/Scl-75; Rrp45p; RRP45; p5; p6; Polymyositis/scleroderma autoantigen 75 kDa; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen

Exosome Component 9 (EXOSC9)
CCC M479
HGNC 9137
MGI 1355319
PubMed 23892402
RGD 1307888
UniProt Q06265
Wiki EXOSC9

Antinucleolar antibodies are found in patients with scleroderma or polymyositis or in patients with overlap of these 2 syndromes. The 2 most prominent proteins in this PMSCL autoantigen complex, PMSCL1 and PMSCL2, are detected as 75- and 100-kD molecules, respectively. The deduced 355-amino acid protein contains a high proportion of charged residues at its C terminus, including a string suggestive of a nuclear or nucleolar localization signal. Northern blot analysis revealed expression of a 1.6-kb PMSCL1 transcript in 2 leukemia cell lines. SDS-PAGE and immunoblot analysis showed that the recombinant protein is expressed at a size close to that of the native protein, which is considerably higher than the predicted size of 39 kD, probably due to acidic residues at the C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 9 (EXOSC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 9 (EXOSC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 9 (EXOSC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 9 (EXOSC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 9 (EXOSC9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 9 (EXOSC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 9 (EXOSC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 9 (EXOSC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 9 (EXOSC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 9 (EXOSC9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 9 (EXOSC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 9 (EXOSC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 9 (EXOSC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 9 (EXOSC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 9 (EXOSC9) ELISA Kit Customized Service Offer
  1. "Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex."J. Exp. Med. 173:941-952(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus."J. Biol. Chem. 278:30698-30704(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases."Genes Dev. 13:2148-2158(1999) [PubMed] [Europe PMC] [Abstract]
  5. "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs."Cell 107:451-464(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements."EMBO J. 21:165-174(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells."Mol. Cell 21:437-443(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome."RNA 12:1810-1816(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways."RNA 13:1027-1035(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Dis3-like 1: a novel exoribonuclease associated with the human exosome."EMBO J. 29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage."Genes Dev. 27:2227-2232(2013) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Reconstitution, activities, and structure of the eukaryotic RNA exosome."Cell 127:1223-1237(2006) [PubMed] [Europe PMC] [Abstract]
  23. ErratumCell 131:188-189(2007)