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Exosome Component 8 (EXOSC8)

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OIP2; RRP43; Rrp43p; EAP2; p9; CIP3; CBP-Interacting Protein 3; Opa Interacting Protein 2

Exosome Component 8 (EXOSC8)
CCC M478
HGNC 17035
MGI 1916889
PubMed 12419256
RGD 1306169
UniProt Q96B26
Wiki EXOSC8
Neisseria gonorrhoeae opacity-associated (Opa) proteins are a family of outer membrane proteins involved in gonococcal adhesion to and invasion of human cells. Opa expression appears to be necessary for gonococcal disease. Sequence analysis predicted that the partial OIP2 cDNA encodes a 265-amino acid peptide that is likely to be the C terminus of a longer protein. OIP2 contains a cluster of basic residues, but unlike OIP1, OIP4, and OIP5, it has no cysteine motif. The mammalian exosome is required for rapid degradation of ARE-containing RNAs but not for poly(A) shortening. The mammalian exosome does not recognize ARE-containing RNAs on its own. ARE recognition required certain ARE-binding proteins that could interact with the exosome and recruit it to unstable RNAs, thereby promoting their rapid degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 8 (EXOSC8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 8 (EXOSC8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 8 (EXOSC8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 8 (EXOSC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 8 (EXOSC8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 8 (EXOSC8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 8 (EXOSC8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 8 (EXOSC8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 8 (EXOSC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 8 (EXOSC8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exosome Component 8 (EXOSC8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exosome Component 8 (EXOSC8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exosome Component 8 (EXOSC8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exosome Component 8 (EXOSC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exosome Component 8 (EXOSC8) ELISA Kit Customized Service Offer
  1. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth."Mol. Microbiol. 27:171-186(1998) [PubMed] [Europe PMC] [Abstract]
  4. "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs."Cell 107:451-464(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring."J. Mol. Biol. 323:653-663(2002) [PubMed] [Europe PMC] [Abstract]
  6. "A protein interaction framework for human mRNA degradation."Genome Res. 14:1315-1323(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome."RNA 12:1810-1816(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways."RNA 13:1027-1035(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Dis3-like 1: a novel exoribonuclease associated with the human exosome."EMBO J. 29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia." Nat. Commun. 5:4287-4287(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Reconstitution, activities, and structure of the eukaryotic RNA exosome."Cell 127:1223-1237(2006) [PubMed] [Europe PMC] [Abstract]
  14. ErratumCell 131:188-189(2007)