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AT Hook Transcription Factor (AKNA)

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AT Hook Transcription Factor (AKNA)
CCC M470
HGNC 24108
MGI 2140340
PubMed 11268217
RGD 1308202
UniProt Q7Z591
Sequence analysis predicted that the 633-amino acid protein contains an AT-hook motif (RTRGRPADS) and 3 PEST regions. Northern blot analysis detected a 4.0-kb transcript predominantly in lymphoid tissue, with highest expression in spleen, lymph nodes, and peripheral blood leukocytes, lower expression in thymus, and undetectable expression in fetal liver and adult bone marrow. In addition, AKNA was expressed by B and T lymphocytes, natural killer cells, and CD1A-positive/CD14-negative dendritic cells. Immunofluorescence microscopy demonstrated a nuclear localization in a B lymphoma transfected with AKNA-GFP. Immunohistochemical analysis showed expression of AKNA predominantly in germinal centers of secondary lymphoid organs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT Hook Transcription Factor (AKNA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT Hook Transcription Factor (AKNA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT Hook Transcription Factor (AKNA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT Hook Transcription Factor (AKNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT Hook Transcription Factor (AKNA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT Hook Transcription Factor (AKNA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT Hook Transcription Factor (AKNA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT Hook Transcription Factor (AKNA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT Hook Transcription Factor (AKNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT Hook Transcription Factor (AKNA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT Hook Transcription Factor (AKNA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT Hook Transcription Factor (AKNA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT Hook Transcription Factor (AKNA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT Hook Transcription Factor (AKNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT Hook Transcription Factor (AKNA) ELISA Kit Customized Service Offer
  1. "The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation."DNA Cell Biol. 24:325-338(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA."Nature 410:383-387(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]