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SMG1 Homolog (SMG1)

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LIP; ATX; Phosphatidylinositol 3-Kinase-Related Kinase; Serine/threonine-protein kinase SMG1; Lambda/iota protein kinase C-interacting protein

SMG1 Homolog (SMG1)
CCC M456
HGNC 30045
MGI 2444194
PubMed 21490678
UniProt Q96Q15
Wiki SMG1
Members of the phosphatidylinositol kinase-related kinase (PIKK) family, such as SMG1, play central roles in cell growth and stress response pathways. SMG1 is involved in nonsense-mediated mRNA decay, genotoxic and oxidative stress pathways, and TNF-induced apoptosis.
The deduced 3,031-amino acid protein has a calculated molecular mass of 340 kD and contains a conserved ATP-binding site, a DXXXXN and a DXX motif within the catalytic domain, and a short FATC C-terminal region common in PIK-related kinases. Northern blot analysis detected wide expression of an 11.6-kb transcript in multiple tissues and cells, with highest expression in heart, skeletal muscle, kidney, and liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SMG1 Homolog (SMG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SMG1 Homolog (SMG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SMG1 Homolog (SMG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SMG1 Homolog (SMG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SMG1 Homolog (SMG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SMG1 Homolog (SMG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SMG1 Homolog (SMG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SMG1 Homolog (SMG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SMG1 Homolog (SMG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SMG1 Homolog (SMG1) ELISA Kit Customized Service Offer
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  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay."Genes Dev. 23:1091-1105(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
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  21. "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability."Genes Dev. 24:1939-1950(2010) [PubMed] [Europe PMC] [Abstract]
  22. "AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay."Sci. Signal. 3:RA27-RA27(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8."Genes Dev. 25:153-164(2011) [PubMed] [Europe PMC] [Abstract]
  26. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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