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Canopy 3 Homolog (CNPY3)

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TNRC5; CAG4A; ERDA5; PRAT4A; Trinucleotide Repeat Containing 5; CTG repeat protein 4a; Expanded repeat-domain protein CAG/CTG 5; Protein associated with TLR4

Canopy 3 Homolog (CNPY3)
CCC M448
HGNC 11968
MGI 1919279
RGD 1597709
UniProt Q9BT09
PRAT4A is associated with the immature form of TLR4 and regulates its cell surface expression .The 278-amino acid PRAT4A protein has a 37-amino acid N-terminal signal sequence, a canonical N-glycosylation site, and 6 cys residues. It shares significant homology with mouse Prat4a and human PRAT4B. Northern blot analysis detected Prat4a expression in all mouse tissues examined.
Knockdown of PRAT4A diminished TLR4/MD2 expression, as well as lipopolysaccharide responsiveness. Human PRAT4A bound hypoglycosylated mouse Tlr4 with or without Md2, but it did not bind mature Tlr4/Md2, in human and mouse cells. PRAT4A has a role in TLR4 maturation and glycosylation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Canopy 3 Homolog (CNPY3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Canopy 3 Homolog (CNPY3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Canopy 3 Homolog (CNPY3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Canopy 3 Homolog (CNPY3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Canopy 3 Homolog (CNPY3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Canopy 3 Homolog (CNPY3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Canopy 3 Homolog (CNPY3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Canopy 3 Homolog (CNPY3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Canopy 3 Homolog (CNPY3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Canopy 3 Homolog (CNPY3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Canopy 3 Homolog (CNPY3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Canopy 3 Homolog (CNPY3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Canopy 3 Homolog (CNPY3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Canopy 3 Homolog (CNPY3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Canopy 3 Homolog (CNPY3) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "cDNAs with long CAG trinucleotide repeats from human brain."Hum. Genet. 100:114-122(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
  8. ErratumNat. Commun. 3:653-653(2012)
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]