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DNA Damage Regulated Autophagy Modulator 2 (DRAM2)

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TMEM77; Transmembrane Protein 77

DNA Damage Regulated Autophagy Modulator 2 (DRAM2)
CCC M445
HGNC 28769
MGI 1914421
PubMed 22935150
RGD 1564099
UniProt Q6UX65
The deduced 266-amino acid DRAM2 protein shares 45% identity with DRAM1. Northern blot analysis detected variable expression of DRAM2 in most tissues examined, with highest expression in placenta and heart and little to no expression in brain and thymus. Immunohistochemical analysis showed that DRAM2 colocalized with a lysosomal marker.
The deduced 266-amino acid protein has 6 putative transmembrane domains and a unique 21-amino acid C-terminal region not found in DRAM1. Western blot analysis detected endogenous DRAM2 at an apparent molecular mass of 35 kD in HEK293 cells. Immunohistochemical analysis showed that DRAM1 and DRAM2 colocalized in lysosomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Regulated Autophagy Modulator 2 (DRAM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Regulated Autophagy Modulator 2 (DRAM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Regulated Autophagy Modulator 2 (DRAM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Regulated Autophagy Modulator 2 (DRAM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Damage Regulated Autophagy Modulator 2 (DRAM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Damage Regulated Autophagy Modulator 2 (DRAM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Damage Regulated Autophagy Modulator 2 (DRAM2) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death."Biochem. Biophys. Res. Commun. 390:1340-1344(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy."Cell Cycle 8:2260-2265(2009) [PubMed] [Europe PMC] [Abstract]