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E74 Like Factor 3 (ELF3)

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ESX; EPR-1; ESE-1; ERT; JEN; ETS-related transcription factor Elf-3; Epithelial-restricted with serine box; Epithelium-specific Ets transcription factor 1

E74 Like Factor 3 (ELF3)
CCC M439
HGNC 3318
MGI 1101781
RGD 1310687
UniProt P78545
Oettgen et al. (1997) isolated and characterized a novel member of the ETS transcription factor family , which they called ESX (also known as ESS-E). This was the first ETS factor and one of only a few transcription factors known to be exclusively expressed in epithelial cells. ESX contains 2 putative DNA-binding domains: an ETS domain and an A/T hook domain.By scanning mutagenesis, Kwon et al. (2003) identified a functional ESE1 site in the promoter region of MIP3-alpha (CCL20) expressed by Caco-2 human intestinal epithelial cells.Oettgen et al. (1999) determined that the ELF3 gene contains 9 exons spanning approximately 5.8 kb of genomic DNA.By fluorescence in situ hybridization (FISH), Oettgen et al. (1997) mapped the ESX gene to 1q32. By the same method, Tymms et al. (1997) refined the location to 1q32.2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E74 Like Factor 3 (ELF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E74 Like Factor 3 (ELF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E74 Like Factor 3 (ELF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E74 Like Factor 3 (ELF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for E74 Like Factor 3 (ELF3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E74 Like Factor 3 (ELF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E74 Like Factor 3 (ELF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E74 Like Factor 3 (ELF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E74 Like Factor 3 (ELF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for E74 Like Factor 3 (ELF3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E74 Like Factor 3 (ELF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E74 Like Factor 3 (ELF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E74 Like Factor 3 (ELF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E74 Like Factor 3 (ELF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for E74 Like Factor 3 (ELF3) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family."Mol. Cell. Biol. 17:4419-4433(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis."Nucleic Acids Res. 25:4287-4295(1997) [PubMed] [Europe PMC] [Abstract]
  3. "ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis."Oncogene 14:1617-1622(1997) [PubMed] [Europe PMC] [Abstract].
  4. "A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer."Oncogene 15:2449-2462(1997) [PubMed] [Europe PMC] [Abstract].
  5. "A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor."J. Biol. Chem. 273:110-117(1998) [PubMed] [Europe PMC] [Abstract].
  6. "Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)."Oncogene 18:3682-3695(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression."Gene 292:129-140(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Partially unspliced and fully spliced ELF3 mRNA, including a new Alu element in human breast cancer."Breast Cancer Res. Treat. 83:171-187(2004) [PubMed] [Europe PMC] [Abstract].
  9. "Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells."Oncogene 19:151-154(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation."Oncogene 19:1941-1949(2000) [PubMed] [Europe PMC] [Abstract]
  11. "ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene."J. Biol. Chem. 276:3302-3309(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Sequence-specific enhancer binding protein is responsible for the differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric cancer cell lines: implication for the loss of TGF-beta type II receptor expression."Oncogene 20:1235-1245(2001) [PubMed] [Europe PMC] [Abstract]
  13. "ErbB2 activation of ESX gene expression."Oncogene 21:3934-3938(2002) [PubMed] [Europe PMC] [Abstract]
  14. "The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression."DNA Cell Biol. 22:79-94(2003) [PubMed] [Europe PMC] [Abstract]
  15. "ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells."J. Biol. Chem. 278:875-884(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation."J. Biol. Chem. 278:17792-17799(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins."J. Biol. Chem. 278:21378-21387(2003) [PubMed] [Europe PMC] [Abstract]
  18. "ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation."J. Biol. Chem. 279:12794-12803(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86."J. Biol. Chem. 279:25241-25250(2004) [PubMed] [Europe PMC] [Abstract]
  20. "The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism."Mol. Cell. Biol. 24:5548-5564(2004) [PubMed] [Europe PMC] [Abstract]
  21. "ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells."Oncogene 23:1766-1779(2004) [PubMed] [Europe PMC] [Abstract]
  22. "The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes."FEBS J. 272:1676-1687(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Identification of an epithelial-specific enhancer regulating ESX expression."Gene 367:118-125(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3."J. Biol. Chem. 281:38941-38950(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Nine-amino-acid transactivation domain: establishment and prediction utilities."Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
  26. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Solution structure of the N-terminal SAM-domain of E74-like factor 3."Submitted (JUL-2007) to the PDB data bank