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RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1)

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RNA polymerase-associated protein RTF1 homolog

RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1)
CCC M434
HGNC 28996
MGI 1309480
PubMed 21677718
RGD 1310654
UniProt Q92541
Wiki RTF1
By sequencing clones obtained from a size-fractionated immature myeloid cell line cDNA library, Nagase et al. (1996) cloned RTF1, which they designated KIAA0252. Northern blot analysis detected high expression in skeletal muscle and moderate expression in all other tissues and cell lines examined.
By searching databases for homologs of yeast Rtf1, Warner et al. (2007) identified human RTF1. The deduced protein contains 585 amino acids. Two amino acid clusters, including 26 invariant residues, are highly conserved in human, yeast, and nematode RTF1.Warner et al. (2007) showed that yeast Rtf1 is a component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RTF1, Paf1/RNA Polymerase II Complex Component, Homolog (RTF1) ELISA Kit Customized Service Offer
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity." Cell Stem Cell 4:403-415(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS."Cell 140:491-503(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the plus-3 domain of human KIAA0252 protein."Submitted (JUN-2006) to the PDB data bank
  13. "Structure and DNA binding of the human Rtf1 Plus3 domain."Structure 16:149-159(2008) [PubMed] [Europe PMC] [Abstract]