≡

SH2 Domain Binding Protein 1 (SH2BP1)

[Edit]

CTR9; TSBP; p150TSP; Tetratricopeptide Repeat Containing; Ctr9,Paf1/RNA Polymerase II Complex Component,Homolog; RNA polymerase-associated protein CTR9 homolog

SH2 Domain Binding Protein 1 (SH2BP1)
CCC M420
HGNC 16850
MGI 109345
PubMed 19277985
RGD 1311097
UniProt Q6PD62
CTR9, parafibromin (CDC73), LEO1, and PAF1 form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex.
The N-terminal two-thirds of the deduced 1,173-amino acid protein contains 15 tetratricopeptide repeats (TPRs), and the C-terminal third contains a serine- and glutamic acid-rich SH2-binding domain. Mouse and human SH2BP1 share 98.6% amino acid identity. Northern blot analysis detected expression in all mouse tissues examined. Western blot analysis of a human B-cell lymphoma cell line detected endogenous SH2BP1 at an apparent molecular mass of 150 kD. Immunolocalization of Sh2bp1 in mouse fibroblasts revealed a speckled nuclear staining pattern.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH2 Domain Binding Protein 1 (SH2BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH2 Domain Binding Protein 1 (SH2BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH2 Domain Binding Protein 1 (SH2BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH2 Domain Binding Protein 1 (SH2BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH2 Domain Binding Protein 1 (SH2BP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH2 Domain Binding Protein 1 (SH2BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH2 Domain Binding Protein 1 (SH2BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH2 Domain Binding Protein 1 (SH2BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH2 Domain Binding Protein 1 (SH2BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH2 Domain Binding Protein 1 (SH2BP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH2 Domain Binding Protein 1 (SH2BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH2 Domain Binding Protein 1 (SH2BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH2 Domain Binding Protein 1 (SH2BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH2 Domain Binding Protein 1 (SH2BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH2 Domain Binding Protein 1 (SH2BP1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The human PAF complex coordinates transcription with events downstream of RNA synthesis."Genes Dev. 19:1668-1673(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity." Cell Stem Cell 4:403-415(2009) [PubMed] [Europe PMC] [Abstract]
  12. "DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation."Genes Dev. 23:2765-2777(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis."Cancer Cell 17:609-621(2010) [PubMed] [Europe PMC] [Abstract]
  15. "The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS."Cell 140:491-503(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Transcriptional activators enhance polyadenylation of mRNA precursors."Mol. Cell 41:409-418(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]