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Trichorhinophalangeal Syndrome Protein I (TRPS1)

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LGCR; Tricho-rhino-phalangeal syndrome type I protein; Zinc finger protein GC79

Trichorhinophalangeal Syndrome Protein I (TRPS1)
CCC M396
HGNC 12340
MGI 1927616
PubMed 23133399
RGD 1311883
UniProt Q9UHF7
TRPS1 encodes a GATA-like transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III.Region A covers 89 amino acids (635-723), spanning 3 potential C2H2 zinc finger structures, and region B covers the 100 most C-terminal amino acids (1182-1281) containing the IKAROS-like motif. DNCL1 colocalized with TRPS1 in dot-like structures in the cell nucleus. An electrophoretic mobility shift assay showed that the interaction of DNCL1 and TRPS1 lowered the binding of TRPS1 to the GATA consensus sequence.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trichorhinophalangeal Syndrome Protein I (TRPS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trichorhinophalangeal Syndrome Protein I (TRPS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trichorhinophalangeal Syndrome Protein I (TRPS1) Polyclonal Antibody Customized Service Offer
Assay Kits SEM396Hu ELISA Kit for Trichorhinophalangeal Syndrome Protein I (TRPS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trichorhinophalangeal Syndrome Protein I (TRPS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trichorhinophalangeal Syndrome Protein I (TRPS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trichorhinophalangeal Syndrome Protein I (TRPS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trichorhinophalangeal Syndrome Protein I (TRPS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trichorhinophalangeal Syndrome Protein I (TRPS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trichorhinophalangeal Syndrome Protein I (TRPS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trichorhinophalangeal Syndrome Protein I (TRPS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trichorhinophalangeal Syndrome Protein I (TRPS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trichorhinophalangeal Syndrome Protein I (TRPS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trichorhinophalangeal Syndrome Protein I (TRPS1) ELISA Kit Customized Service Offer
  1. "Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I."Nat. Genet. 24:71-74(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a zinc-finger protein and its association with apoptosis in prostate cancer cells."J. Natl. Cancer Inst. 92:1414-1421(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."J. Biol. Chem. 278:38780-38785(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "SUMOylation modulates transcriptional repression by TRPS1."Biol. Chem. 388:381-390(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3."Dev. Biol. 328:40-53(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Genotypic and phenotypic spectrum in tricho-rhino-phalangeal syndrome types I and III." Am. J. Hum. Genet. 68:81-91(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Missense mutation of TRPS1 in a family of tricho-rhino-phalangeal syndrome type III."Am. J. Med. Genet. 107:26-29(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Novel missense mutations in the TRPS1 transcription factor define the nuclear localization signal."Eur. J. Hum. Genet. 12:121-126(2004) [PubMed] [Europe PMC] [Abstract]