≡

Suppressor Of Ty 3 Homolog (SUPT3H)

[Edit]

SPT3; SPT3L; SPT3-like protein; Transcription initiation protein SPT3 homolog

Suppressor Of Ty 3 Homolog (SUPT3H)
CCC M395
HGNC 11466
MGI 1923723
PubMed 9674425
UniProt O75486
Wiki SUPT3H
Ogryzko et al. (1998) identified a human polypeptide, which they called SPT3, as a subunit of the P/CAF complex. The predicted 317-amino acid protein shows 51% amino acid sequence similarity with yeast SPT3. Struhl and Moqtaderi (1998) reviewed the potential roles of the PCAF complex in transcription.
By searching for genes within a region of chromosome 6 associated with cleidocranial dysplasia, followed by database analysis and screening of a human craniofacial cDNA library, Yu et al. (1998) cloned the SUPT3H gene. The deduced protein contains 399 amino acids.By genomic sequence analysis, Yu et al. (1998) mapped the SUPT3H gene to chromosome 6p21.3-p21.1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Ty 3 Homolog (SUPT3H) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Ty 3 Homolog (SUPT3H) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Ty 3 Homolog (SUPT3H) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Ty 3 Homolog (SUPT3H) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Ty 3 Homolog (SUPT3H) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Suppressor Of Ty 3 Homolog (SUPT3H) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Suppressor Of Ty 3 Homolog (SUPT3H) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Suppressor Of Ty 3 Homolog (SUPT3H) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Suppressor Of Ty 3 Homolog (SUPT3H) CLIA Kit Customized Service Offer
n/a ELISA Kit for Suppressor Of Ty 3 Homolog (SUPT3H) ELISA Kit Customized Service Offer
  1. "Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor Spt3 (SUPT3H)."Genomics 53:90-96(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Histone-like TAFs within the PCAF histone acetylase complex."Cell 94:35-44(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID."J. Biol. Chem. 273:23781-23785(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily."Mol. Cell 2:869-875(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction."J. Biol. Chem. 274:18285-18289(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo."Mol. Cell. Biol. 21:6782-6795(2001) [PubMed] [Europe PMC] [Abstract]
  10. "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing."Mol. Cell 29:92-101(2008) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]